3032624-35-1
3032624-35-1
Chemical Structure
HPK1-IN-40-d2
- CAS No.: 3032624-35-1
- Formula:C24H20D2FN7O3
- Molecular Weight:477.49
InChIKey: RWTXXGPUNDKBLW-OMVVLXAOSA-N
SMILES: OC([2H])([C@@H](NC1=NC(NC2=CC(C(C)(N3)C)=C(C=C2)C3=O)=NC=C1C4=NN=CO4)C5=CC=C(C=C5)F)[2H]
Biological Activity: HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity[1].
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HPK1-IN-40-d2 | HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity. | |||||||||||||||||||||
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