3032746-99-6
3032746-99-6
Chemical Structure
GPX4-IN-9
- CAS No.: 3032746-99-6
- Formula:C26H21N3O2S2
- Molecular Weight:471.59
InChIKey: ATHNKGWONRDIKH-UHFFFAOYSA-N
SMILES: O=S(C(C=C1)=CC=C1CN(C2=CC=C(C=C2)C3=NC4=C(S3)C=CC=C4)CC#C)(N(C#C)C)=O
Biological Activity: GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research[1].
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GPX4-IN-9 | 99.18% | GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research. | ||||||||||||||||||||
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References
- [1]. Tang Z, et al. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in PancrTang Z, et al. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy. J Med Chem. 2024 Feb 8;67(3):1872-1887.eatic Cancer Therapy. J Med Chem. 2024 Feb 8;67(3):1872-1887. [Content Brief]
