3032760-90-7
3032760-90-7
Chemical Structure
EGFR T790M/L858R-IN-7
- CAS No.: 3032760-90-7
- Formula:C27H29N7O4
- Molecular Weight:515.56
InChIKey: ZLYUPHXMUJICTA-GQCTYLIASA-N
SMILES: O=C(NC1=CC(NC2=NC=CC(N3C=CC4=CC=CN=C43)=N2)=C(OC)C=C1OC)/C=C/CN5CCOCC5
Biological Activity: EGFR T790M/L858R-IN-7 (Compound 72) is a novel pyrimidine compound that inhibits the EGFR T790M and L858R mutation with a high efficacy (93% inhibition rate at 0.05 μM). EGFR T790M/L858R-IN-7 functions by specifically binding to the kinase domain of EGFR, thereby inhibiting its phosphorylation activity[1].
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EGFR T790M/L858R-IN-7 | EGFR T790M/L858R-IN-7 (Compound 72) is a novel pyrimidine compound that inhibits the EGFR T790M and L858R mutation with a high efficacy (93% inhibition rate at 0.05 μM). EGFR T790M/L858R-IN-7 functions by specifically binding to the kinase domain of EGFR, thereby inhibiting its phosphorylation activity. | |||||||||||||||||||||
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