3033038-38-6
3033038-38-6
Chemical Structure
Tubulin inhibitor 22
- CAS No.: 3033038-38-6
- Formula:C20H17BrFNO4
- Molecular Weight:434.26
IUPAC Name: (Z)-3-(6-bromo-1H-indol-3-yl)-2-fluoro-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
InChIKey: MGNDDHVWHPNTDF-UUASQNMZSA-N
SMILES: O=C(C1=CC(OC)=C(OC)C(OC)=C1)/C(F)=C/C2=CNC3=C2C=CC(Br)=C3
Biological Activity: Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of tubulin with anti-angiogenesis and anti-cancer properties. Tubulin inhibitor 22 arrests MGC-803 cell cycle at G2/M phase. Tubulin inhibitor 22 dose-dependently causes Caspase-induced apoptosis of MGC-803 cells through mitochondrial dysfunction[1].
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Tubulin inhibitor 22 | Tubulin inhibitor 22 (compound 4c) is a potent inhibitor of tubulin with anti-angiogenesis and anti-cancer properties. Tubulin inhibitor 22 arrests MGC-803 cell cycle at G2/M phase. Tubulin inhibitor 22 dose-dependently causes Caspase-induced apoptosis of MGC-803 cells through mitochondrial dysfunction. | |||||||||||||||||||||
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