3033043-66-9
3033043-66-9
Chemical Structure
FGFR4-IN-9
- CAS No.: 3033043-66-9
- Formula:C24H22ClF3N4O4
- Molecular Weight:522.90
IUPAC Name: (E)-4-carbamoyl-1-(3-(4-((hydroxyimino)methyl)pyridin-1-ium-1-yl)propyl)pyridin-1-ium bromide
InChIKey: WVBQWKJLAMNYMS-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(F)=CC(Cl)=C1NC2=NC(C)=C(C(C)=N2)OCC3=C(C(OC)=CC(OC)=C3F)F)=O
Biological Activity: FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC50 of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC[1].
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FGFR4-IN-9 | FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC50 of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC. | |||||||||||||||||||||
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References
- [1]. Chaudhary CL, et al. 6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation. J Enzyme Inhib Med Chem. 2022 Dec;37(1):844-856. [Content Brief]
