3033087-05-4
Chemical Structure
hDHODH-IN-10
- CAS No.: 3033087-05-4
- Formula:C21H15ClF4N2O4
- Molecular Weight:470.80
IUPAC Name: (S,Z)-N-(4-(2-chlorobenzoyl)-2-fluoro-5-((1,1,1-trifluoropropan-2-yl)oxy)phenyl)-2-cyano-3-hydroxybut-2-enamide
InChIKey: FEOYUARGFWZVAW-HKLRHMNMSA-N
SMILES: C/C(O)=C(C(NC1=C(C=C(C(O[C@H](C(F)(F)F)C)=C1)C(C2=C(C=CC=C2)Cl)=O)F)=O)\C#N
Biological Activity: hDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer[1].
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hDHODH-IN-10 | hDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer. | |||||||||||||||||||||
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