3033571-35-3
3033571-35-3
Chemical Structure
EZH2/HSP90-IN-29
- CAS No.: 3033571-35-3
- Formula:C40H48N4O6
- Molecular Weight:680.83
InChIKey: HFGQPOCPRWCSRT-UHFFFAOYSA-N
SMILES: O=C(NCC1=C(C=C(NC1=O)C)C)C2=CC(C3=CC=CC(N(C(C4=CC(C(C)C)=C(C=C4O)O)=O)C)=C3)=CC(N(C5CCOCC5)CC)=C2C
Biological Activity: EZH2/HSP90-IN-29 is a dual inhibitor for EZH2 and HSP90, with IC50s of 6.29 nM and 60.1 nM, for EZH2 and HSP90, respectively. EZH2/HSP90-IN-29 increases apoptosis/necrosis-related gene expression, induces cell cycle arrest at M phase and inhibits reactive oxygen species (ROS) catabolism pathway. EZH2/HSP90-IN-29 is able to cross the blood-brain-barrier (BBB)[1].
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EZH2/HSP90-IN-29 | EZH2/HSP90-IN-29 is a dual inhibitor for EZH2 and HSP90, with IC50s of 6.29 nM and 60.1 nM, for EZH2 and HSP90, respectively. EZH2/HSP90-IN-29 increases apoptosis/necrosis-related gene expression, induces cell cycle arrest at M phase and inhibits reactive oxygen species (ROS) catabolism pathway. EZH2/HSP90-IN-29 is able to cross the blood-brain-barrier (BBB). | |||||||||||||||||||||
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