3033615-55-0
3033615-55-0
Chemical Structure
GLS1 Inhibitor-6
- CAS No.: 3033615-55-0
- Formula:C37H52N6O3S
- Molecular Weight:660.91
IUPAC Name: N-((1-hexylpiperidin-4-yl)methyl)-3-((2-(1-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethoxy)methyl)benzamide
InChIKey: KBMVEWMZBAAPSR-UHFFFAOYSA-N
SMILES: O=C(NCC1CCN(CCCCCC)CC1)C2=CC=CC(COCCC3CCN(C4=NN=C(NC(CC5=CC=CC=C5)=O)S4)CC3)=C2
Biological Activity: GLS1 Inhibitor-6 (Compound 24y) is an orally active, potent and selective glutaminase 1 (GLS1) inhibitor (IC50=68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces apoptosis[1].
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GLS1 Inhibitor-6 | GLS1 Inhibitor-6 (Compound 24y) is an orally active, potent and selective glutaminase 1 (GLS1) inhibitor (IC50=68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces apoptosis. | |||||||||||||||||||||
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