3033846-29-3
3033846-29-3
Chemical Structure
SIK-IN-1
- CAS No.: 3033846-29-3
- Formula:C23H24N6OS
- Molecular Weight:432.54
InChIKey: AWLHPMOLJAWKDL-UHFFFAOYSA-N
SMILES: N#CC1=C(NC)C=CC2=NC=C(C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3)N21
Biological Activity: SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SIK1, SIK2 and SIK3 with IC50s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 4 nM in human macrophages[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SIK-IN-1 | 98.91% | SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SIK1, SIK2 and SIK3 with IC50s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 4 nM in human macrophages. | ||||||||||||||||||||
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