3034216-44-6
3034216-44-6
Chemical Structure
CDD-1653
- CAS No.: 3034216-44-6
- Formula:C21H22N6O4S
- Molecular Weight:454.50
InChIKey: MHMPZSOMHQSWEN-UHFFFAOYSA-N
SMILES: O=C1N(CCN(C1)C2=NC(NC3=CC=CC(S(=O)(N)=O)=C3)=NC=C2OC)C4=CC=CC=C4
Biological Activity: CDD-1653 is a potent and selective BMPR2 inhibitor with an IC50 of 2.8 nM. CDD-1653 inhibits the catalytic activity of BMPR2 by competitively binding to its ATP pocket, specifically blocking BMP-induced downstream signaling (particularly inhibiting SMAD1/5 phosphorylation), thereby suppressing the expression of related genes. CDD-1653 can be used for research on cancer, bone diseases, and vascular and endothelial dysfunction[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CDD-1653 | 99.38% | CDD-1653 is a potent and selective BMPR2 inhibitor with an IC50 of 2.8 nM. CDD-1653 inhibits the catalytic activity of BMPR2 by competitively binding to its ATP pocket, specifically blocking BMP-induced downstream signaling (particularly inhibiting SMAD1/5 phosphorylation), thereby suppressing the expression of related genes. CDD-1653 can be used for research on cancer, bone diseases, and vascular and endothelial dysfunction. | ||||||||||||||||||||
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