3034312-17-6
3034312-17-6
Chemical Structure
JH-XVII-10
- CAS No.: 3034312-17-6
- Formula:C22H18F4N8O
- Molecular Weight:486.42
IUPAC Name: (Z)-22-fluoro-31,5-dimethyl-6-oxo-13-(trifluoromethyl)-11H,21H,31H-5-aza-2(3,5)-pyrrolo[2,3-b]pyridina-1(4,1),3(4,3)-dipyrazolacyclononaphane-35-carbonitrile
InChIKey: YVQOYBIBWBAHKH-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=NN2C=C1C3=C(F)NC4=NC=C(C=C43)C5=C(C#N)N(C)N=C5CN(C)C(CCC2)=O
Biological Activity: JH-XVII-10 is a potent, selective and orally active DYRK1A and DYRK1B inhibitor with IC50s of 3 nM and 5 nM for DYRK1A and DYRK1B, respectively. JH-XVII-10 shows antitumor efficacy in neck squamous cell carcinoma (HNSCC) cell lines[1].
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JH-XVII-10 | JH-XVII-10 is a potent, selective and orally active DYRK1A and DYRK1B inhibitor with IC50s of 3 nM and 5 nM for DYRK1A and DYRK1B, respectively. JH-XVII-10 shows antitumor efficacy in neck squamous cell carcinoma (HNSCC) cell lines. | |||||||||||||||||||||
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