3034402-59-7
3034402-59-7
Chemical Structure
PRMT5/EGFR-IN-1
- CAS No.: 3034402-59-7
- Formula:C27H22F6N2O2
- Molecular Weight:520.47
InChIKey: MOOWKXDYPKYTBJ-UHFFFAOYSA-N
SMILES: COC1=CC(C2NCCC3=C2NC4=CC=CC=C43)=CC=C1OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5
Biological Activity: PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual PRMT5/EGFR inhibitor, with IC50s of 15.47 and 19.31 μM, respectively. PRMT5/EGFR-IN-1 exhibits antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines. PRMT5/EGFR-IN-1 has favorable in vivo PK and PD properties. PRMT5/EGFR-IN-1 can significantly inhibit the growth of MCF7 orthotopic xenograft tumors[1].
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PRMT5/EGFR-IN-1 | PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual PRMT5/EGFR inhibitor, with IC50s of 15.47 and 19.31 μM, respectively. PRMT5/EGFR-IN-1 exhibits antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines. PRMT5/EGFR-IN-1 has favorable in vivo PK and PD properties. PRMT5/EGFR-IN-1 can significantly inhibit the growth of MCF7 orthotopic xenograft tumors. | |||||||||||||||||||||
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