3035493-13-8
3035493-13-8
Chemical Structure
PARP14 inhibitor 1
- CAS No.: 3035493-13-8
- Formula:C23H27FN4O3
- Molecular Weight:426.48
InChIKey: ICYHYDYTVRSSGQ-UHFFFAOYSA-N
SMILES: O=C1NC(N2CC3(C2)CCN(CC3)C(C4CC4)=O)=NC5=CC(OCC6CC6)=CC(F)=C51
Biological Activity: PARP14 inhibitor 1 is an orally active, selective PARP14 inhibitor with an IC50 of 5.52 nM. PARP14 inhibitor 1 exhibits favorable pharmacokinetic properties and in vivo safety. PARP14 inhibitor 1 enhances and stabilizes intracellular endogenous PARP14 protein levels, while effectively reducing the expression levels of IL-4, IL-13 and IL-17A. PARP14 inhibitor 1 can be used in research related to atopic dermatitis[1].
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PARP14 inhibitor 1 | PARP14 inhibitor 1 is an orally active, selective PARP14 inhibitor with an IC50 of 5.52 nM. PARP14 inhibitor 1 exhibits favorable pharmacokinetic properties and in vivo safety. PARP14 inhibitor 1 enhances and stabilizes intracellular endogenous PARP14 protein levels, while effectively reducing the expression levels of IL-4, IL-13 and IL-17A. PARP14 inhibitor 1 can be used in research related to atopic dermatitis. | |||||||||||||||||||||
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