3035510-04-1
3035510-04-1
Chemical Structure
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3
- CAS No.: 3035510-04-1
- Formula:C38H44Cl2N8O7
- Molecular Weight:795.71
InChIKey: LDXNMPUIXQXXMT-XDSPJLLDSA-N
SMILES: O=C(N1CC(N(CC1)CC(NCCOCCOCCN=[N+]=[N-])=O)=O)N2[C@@H](C3=CC=C(C=C3)Cl)[C@@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C
Biological Activity: (4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-30 (HY-181359)[1].
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(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 | (4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-30 (HY-181359). | |||||||||||||||||||||
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