3036368-70-1
3036368-70-1
Chemical Structure
cGAS-IN-3
- CAS No.: 3036368-70-1
- Formula:C21H20Cl2F2N4O2
- Molecular Weight:469.31
InChIKey: WXJAKMBSZUGJQA-OAQYLSRUSA-N
SMILES: FC(F)N(C=C1)N=C1C(C=C2Cl)=C3C4=C(NC3=C2Cl)CC[C@]5(C4)CCN(C(CO)=O)C5
Biological Activity: cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats[1].
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cGAS-IN-3 | cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats. | |||||||||||||||||||||
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