3036456-18-2
Chemical Structure
NIR-BG2
- CAS No.: 3036456-18-2
- Formula:C42H46F2NO8+
- Molecular Weight:730.81
InChIKey: ZNRWLYUUVWBJEH-HGHRUTHGSA-N
SMILES: CCC[N+]1=C(/C=C/C2=C3C(CCC2)=CC4=CC(C(F)F)=C(OCC5=CC=C(C=C5)O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O)O)CO)C=C4O3)C(C)(C)C7=CC=CC=C17
Biological Activity: NIR-BG2 is a fluorescent indicator targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 contains a hemicyanine fluorophore caged by SA-β-Gal; cleavage of its β-galactosyl group by SA-β-Gal generates an electrophilic quinone methide, which can form covalent bonds with adjacent proteins to achieve long-term signal retention. NIR-BG2 activates a near-infrared fluorescent signal upon recognition of SA-β-Gal. NIR-BG2 can be used for non-invasive in vivo imaging of cellular senescence in mouse xenograft models. The excitation/emission wavelengths are 675/708 nm[1][2][3].
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NIR-BG2 | NIR-BG2 is a fluorescent indicator targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 contains a hemicyanine fluorophore caged by SA-β-Gal; cleavage of its β-galactosyl group by SA-β-Gal generates an electrophilic quinone methide, which can form covalent bonds with adjacent proteins to achieve long-term signal retention. NIR-BG2 activates a near-infrared fluorescent signal upon recognition of SA-β-Gal. NIR-BG2 can be used for non-invasive in vivo imaging of cellular senescence in mouse xenograft models. The excitation/emission wavelengths are 675/708 nm. | |||||||||||||||||||||
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References
- [1]. Zhang Y, et al. Recent advances in self-immobilizing fluorescent probes for in vivo imaging. Smart molecules : open access. 2024 Sep;2(3):e20240031. [Content Brief]
- [2]. Liu J, et al. Noninvasive NIR Imaging of Senescence viaIn Situ Labeling. J Med Chem. 2021 Dec 23;64(24):17969-17978. [Content Brief]
- [3]. Park J, et al. Recent Developments in Small-Molecule Fluorescent Probes for Cellular Senescence. Chemosensors. 2024;12(7):141.
