3036530-23-8
3036530-23-8
Chemical Structure
EST1027
- CAS No.: 3036530-23-8
- Formula:C33H35F3N8O2
- Molecular Weight:632.68
InChIKey: NUNSNQLTNNCTMR-NTEUORMPSA-N
SMILES: O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(C(/C=C/C5=CC=C(C(F)(F)F)C=C5)=O)CC4)C=C3)N=C2N1C6CCCC6)N(C)C
Biological Activity: EST1027 is a CDK4 Molecular glue degrader. EST1027 degrades CDK4 by forming a CDK4-EST1027-RNF126 ternary complex. EST1027 can be used for research on cervical cancer[1][2][3].
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EST1027 | EST1027 is a CDK4 Molecular glue degrader. EST1027 degrades CDK4 by forming a CDK4-EST1027-RNF126 ternary complex. EST1027 can be used for research on cervical cancer. | |||||||||||||||||||||
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References
- [1]. Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS central science. 2023 May 24;9(5):915-926. [Content Brief]
- [2]. Hu Y, et al. Molecular glue degrader for tumor treatment. Frontiers in oncology. 2024;14:1512666. [Content Brief]
- [3]. Schaefer D, et al. Recent Advances in Covalent Drug Discovery. Pharmaceuticals (Basel, Switzerland). 2023 Apr 28;16(5):663.
