3037217-70-9
3037217-70-9
Chemical Structure
EYE1090
- CAS No.: 3037217-70-9
- Formula:C22H26ClN7O2
- Molecular Weight:455.94
InChIKey: QDIYNFRLKWXPJE-GDNBJRDFSA-N
SMILES: CCN(CC)CCNC(C1=C(C)NC(/C=C2C(NC3=CC(Cl)=C(N=[N+]=[N-])C=C3\2)=O)=C1C)=O
Biological Activity: EYE1090 is an orally active VEGFR2 inhibitor with an IC50 of 3 nM. EYE1090 inhibits angiogenesis, endothelial migration, VEGFR2-induced retinal leakage, and reduces choroidal neovascularization lesion size in mice. EYE1090 can be used for the research of age-related macular degeneration, diabetic retinopathy, choroidal neovascularization[1].
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EYE1090 | EYE1090 is an orally active VEGFR2 inhibitor with an IC50 of 3 nM. EYE1090 inhibits angiogenesis, endothelial migration, VEGFR2-induced retinal leakage, and reduces choroidal neovascularization lesion size in mice. EYE1090 can be used for the research of age-related macular degeneration, diabetic retinopathy, choroidal neovascularization. | |||||||||||||||||||||
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