3037300-49-2
3037300-49-2
Chemical Structure
MDM2/4-p53-IN-2
- CAS No.: 3037300-49-2
- Formula:C25H17Cl3FN3O3
- Molecular Weight:532.78
IUPAC Name: ethyl (3R,4'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(4-chlorophenyl)-2-oxo-2',4'-dihydrospiro[indoline-3,3'-pyrazole]-5'-carboxylate
InChIKey: HIUSVJZXJUTUQG-CPJSRVTESA-N
SMILES: O=C(OCC)C([C@@H]1C2=CC=CC(Cl)=C2F)=NN([C@]13C(NC4=C3C=CC(Cl)=C4)=O)C5=CC=C(C=C5)Cl
Biological Activity: MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity[1].
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MDM2/4-p53-IN-2 | MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity. | |||||||||||||||||||||
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