3037776-67-0
3037776-67-0
Chemical Structure
Arg-PEG1-Dasa
- CAS No.: 3037776-67-0
- Formula:C33H47ClN12O5S
- Molecular Weight:759.32
InChIKey: UMCJYQURSZMMCC-DEOSSOPVSA-N
SMILES: CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCOC(CCOCCNC([C@@H](N)CCCNC(N)=N)=O)=O)=N1
Biological Activity: Arg-PEG1-Dasa is a mini-PROTAC targeting BCR-ABL. Arg-PEG1-Dasa induces BCR-ABL degradation (EC50 = 0.85 nM) and shows antiproliferative activity in K562 cells (IC50 = 0.36 nM). Arg-PEG1-Dasa can be used for chronic myeloid leukemia research[1].
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Arg-PEG1-Dasa | Arg-PEG1-Dasa is a mini-PROTAC targeting BCR-ABL. Arg-PEG1-Dasa induces BCR-ABL degradation (EC50 = 0.85 nM) and shows antiproliferative activity in K562 cells (IC50 = 0.36 nM). Arg-PEG1-Dasa can be used for chronic myeloid leukemia research. | |||||||||||||||||||||
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