3038480-88-2
3038480-88-2
Chemical Structure
LWG-301
- CAS No.: 3038480-88-2
- Formula:C28H38N8O3S
- Molecular Weight:566.72
IUPAC Name: N-(5-((1-(6-(2-(3-butoxyphenyl)acetamido)pyridazin-3-yl)piperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)pentanamide
InChIKey: DLNIOHJBGKHAOD-UHFFFAOYSA-N
SMILES: CCCCOC1=CC=CC(CC(NC2=NN=C(C=C2)N3CCC(CC3)NC4=NN=C(S4)NC(CCCC)=O)=O)=C1
Biological Activity: LWG-301 is an allosteric inhibitor of Glutaminase 1 (GLS1) with an IC50 value of 7 nM. LWG-301 significantly block glutamine metabolism, increases intracellular ROS, thus induces apoptosis. LWG-301 exhibits moderate antitumor effects in HCT116 xenograft model[1].
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LWG-301 | LWG-301 is an allosteric inhibitor of Glutaminase 1 (GLS1) with an IC50 value of 7 nM. LWG-301 significantly block glutamine metabolism, increases intracellular ROS, thus induces apoptosis. LWG-301 exhibits moderate antitumor effects in HCT116 xenograft model. | |||||||||||||||||||||
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