3038789-74-8
Chemical Structure
Antitumor agent-83
- CAS No.: 3038789-74-8
- Formula:C29H30N6O2
- Molecular Weight:494.59
IUPAC Name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: NXVZVYHGUMZAHM-QVTSOHHYSA-N
SMILES: CN(C1CCN(CC1)C(C2=CC=C(C=C2)N3N=C(/C(C3=O)=N/NC4=CC=CC=C4)C5=CC=CC=C5)=O)C
Biological Activity: Antitumor agent-83 is an activator of pro-apoptotic protein BAX and has significant anti-proliferation effect on tumor cells. Antiumor agent-83 mediates cell Apoptosis by inducing the conformational activation of BAX and has inhibitory effect on A549 cell cycle. Antiumor agent-83 has good metabolic stability and CYPs spectrum in vitro[1].
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Antitumor agent-83 | Antitumor agent-83 is an activator of pro-apoptotic protein BAX and has significant anti-proliferation effect on tumor cells. Antiumor agent-83 mediates cell Apoptosis by inducing the conformational activation of BAX and has inhibitory effect on A549 cell cycle. Antiumor agent-83 has good metabolic stability and CYPs spectrum in vitro. | |||||||||||||||||||||
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