3039954-64-5
3039954-64-5
Chemical Structure
HM-279
- CAS No.: 3039954-64-5
- Formula:C22H25N7O2S
- Molecular Weight:451.54
InChIKey: HACYEVIDLDLIII-UHFFFAOYSA-N
SMILES: NC(C1=C(C2=CC(C(N(C)C)=O)=CN2)SC(N(CC3CC3)C4=CN(CC#CC)N=C4)=N1)=O
Biological Activity: HM-279 is a potent and orally active ALK5 inhibitor with an IC50 of 4.7 nM. HM-279 shows cross-reactivity with ALK7 (IC50 = 6.8 nM), but HM-279 has fair to good selectivity against other TGF-β receptor family kinases, with 4.5-693-fold selectivity. HM-279 demonstrates antitumor activity in vivo through CD8+ T cell immunity. HM-279 can be used for the research of colon cancer[1].
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HM-279 | HM-279 is a potent and orally active ALK5 inhibitor with an IC50 of 4.7 nM. HM-279 shows cross-reactivity with ALK7 (IC50 = 6.8 nM), but HM-279 has fair to good selectivity against other TGF-β receptor family kinases, with 4.5-693-fold selectivity. HM-279 demonstrates antitumor activity in vivo through CD8+ T cell immunity. HM-279 can be used for the research of colon cancer. | |||||||||||||||||||||
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