304008-29-5
304008-29-5
Chemical Structure
Lu AA33810
- CAS No.: 304008-29-5
- Formula:C19H25N3O2S3
- Molecular Weight:423.62
IUPAC Name: N-(((1r,4r)-4-((4,5-dihydrobenzo[2,3]thiepino[4,5-d]thiazol-2-yl)amino)cyclohexyl)methyl)methanesulfonamide
InChIKey: UWSBTSAJZMIHBL-HDJSIYSDSA-N
SMILES: CS(NC[C@@H](CC1)CC[C@H]1NC2=NC3=C(S2)CCSC4=CC=CC=C34)(=O)=O
Biological Activity: Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1][2].
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Lu AA33810 | 98.3% | Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects. | ||||||||||||||||||||
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References
- [1]. Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328(3):900-11. [Content Brief]
- [2]. Domin H,et al. Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence. Psychopharmacology (Berl). 2017 Feb;234(4):631-645. [Content Brief]
