3040383-48-7
3040383-48-7
Chemical Structure
5-LOX/sEH-IN-1
- CAS No.: 3040383-48-7
- Formula:C18H15N7O
- Molecular Weight:345.36
InChIKey: JFHPTROIQVXZHA-UHFFFAOYSA-N
SMILES: N#CC1=C(N)N2C(NC1C3=CC=C(OC)C=C3)=NN=C2C4=CC=CN=C4
Biological Activity: 5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects[1].
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5-LOX/sEH-IN-1 | 5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects. | |||||||||||||||||||||
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