3041025-49-1
3041025-49-1
Chemical Structure
c-Kit-IN-14
- CAS No.: 3041025-49-1
- Formula:C26H25ClFN9O3
- Molecular Weight:565.99
InChIKey: GGUNNAKXTZUDTO-KRWDZBQOSA-N
SMILES: COC[C@H](CN1C=C(C(C)=N1)C2=CC3=C(C=NN3C=C2)C(NC4=C(C=C(C(C5=NN(N=N5)C6CC6)=C4)F)Cl)=O)O
Biological Activity: c-Kit-IN-14 (Compound 1) is a c-kit kinase inhibitor. c-Kit-IN-14 inhibits the phosphorylation of wild-type c-kit, with an IC50 of 0.4 nM for pKIT. c-Kit-IN-14 inhibits Exon 11 KIT, with an IC50 of 0.4 nM. c-Kit-IN-14 can be used in the research of mast cell-mediated diseases such as urticaria[1].
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c-Kit-IN-14 | c-Kit-IN-14 (Compound 1) is a c-kit kinase inhibitor. c-Kit-IN-14 inhibits the phosphorylation of wild-type c-kit, with an IC50 of 0.4 nM for pKIT. c-Kit-IN-14 inhibits Exon 11 KIT, with an IC50 of 0.4 nM. c-Kit-IN-14 can be used in the research of mast cell-mediated diseases such as urticaria. | |||||||||||||||||||||
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