30413-84-4
Chemical Structure
Corydalmine
Synonym(s): L-Corydalmine; TLZ-16
- CAS No.: 30413-84-4
- Formula:C20H23NO4
- Molecular Weight:341.40
IUPAC Name: (S)-2,3,9-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol
InChIKey: DIHXHTWYVOYYDC-INIZCTEOSA-N
SMILES: OC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC
Biological Activity: Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Corydalmine | 99.74% | Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway. | ||||||||||||||||||||
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References
- [1]. S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71. [Content Brief]
- [2]. Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105. [Content Brief]
- [3]. Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47. [Content Brief]
