30439-19-1
Chemical Structure
5-Methoxytryptoline
- CAS No.: 30439-19-1
- Formula:C12H14N2O
- Molecular Weight:202.26
IUPAC Name: 5-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
InChIKey: VPZWHBCLJCKHGZ-UHFFFAOYSA-N
SMILES: O(C1=CC=CC=2NC3=C(C12)CCNC3)C
Biological Activity: 5-Methoxytryptoline acts as a modulator of the Serotonin transporter complex, as well as a ligand for the 5-HT2A and 5-HT2C receptors, with Ki values of 130 nM and 140 nM for the 5-HT2A and 5-HT2C receptors, respectively. 5-Methoxytryptoline inhibits the active uptake of Serotonin (HY-B1473A) and Tryptamine (HY-B2132) in platelets. 5-Methoxytryptoline induces behavioral excitation, cortical electroencephalographic desynchronization, and dose-dependent elevation of plasma prolactin, followed by behavioral sedation and partial recovery of cortical electroencephalographic voltage. 5-Methoxytryptoline antagonizes Reserpine (HY-N0480)-induced sedation, reduced locomotor activity, and hypothermia. 5-Methoxytryptoline exerts dose-dependent effects on behavior and cortical electroencephalographic activity in freely moving rats. 5-Methoxytryptoline can be used in depression-related research[1][2][3][4].
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5-Methoxytryptoline | 5-Methoxytryptoline acts as a modulator of the Serotonin transporter complex, as well as a ligand for the 5-HT2A and 5-HT2C receptors, with Ki values of 130 nM and 140 nM for the 5-HT2A and 5-HT2C receptors, respectively. 5-Methoxytryptoline inhibits the active uptake of Serotonin (HY-B1473A) and Tryptamine (HY-B2132) in platelets. 5-Methoxytryptoline induces behavioral excitation, cortical electroencephalographic desynchronization, and dose-dependent elevation of plasma prolactin, followed by behavioral sedation and partial recovery of cortical electroencephalographic voltage. 5-Methoxytryptoline antagonizes Reserpine (HY-N0480)-induced sedation, reduced locomotor activity, and hypothermia. 5-Methoxytryptoline exerts dose-dependent effects on behavior and cortical electroencephalographic activity in freely moving rats. 5-Methoxytryptoline can be used in depression-related research. | |||||||||||||||||||||
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References
- [1]. Nistico G, et al. Behavioural and electrocortical power spectrum effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats. European journal of pharmacology. 1987 Oct 06;142(1):121-8. [Content Brief]
- [2]. Grella B, et al. Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. [Content Brief]
- [3]. Segonzac A, et al. 5-Methoxytryptoline, a competitive endocoid acting at [3H]imipramine recognition sites in human platelets. Journal of neurochemistry. 1985 Jul;45(1):249-56. [Content Brief]
- [4]. Rovescalli AC, et al. Endocrine effects of 5-methoxytryptoline, 5-hydroxytryptoline and tryptoline, putative modulators of rat serotonergic system. Journal of endocrinological investigation. 1987 Feb;10(1):65-72. [Content Brief]
