3043923-74-3
Chemical Structure
PROTAC SOS1 degrader-10
- CAS No.: 3043923-74-3
- Formula:C51H63F3N10O6
- Molecular Weight:969.10
InChIKey: FUTHCLUTRFIAKK-SNTUXTEOSA-N
SMILES: NC1=CC(C(F)(F)F)=CC([C@@H](C)NC2=C3C(N(C)C(C([C@H]4CC[C@H](C(N5CCN(CC6CCC7(CCN(C(C8=CC=C(OC)C(N9CCC(NC9=O)=O)=C8)=O)CC7)CC6)CC5)=O)CC4)=C3)=O)=NC=N2)=C1
Biological Activity: PROTAC SOS1 degrader-10 is a SOS1 PROTAC degrader dependent on CRBN and the proteasome. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS-mutant cancer cells SW620, A549 and DLD-1, with DC50 values of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits ERK phosphorylation. PROTAC SOS1 degrader-10 suppresses the proliferation of KRAS-mutant cancer cells via antiproliferative activity. PROTAC SOS1 degrader-10 can be used in studies related to KRAS-mutant cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC SOS1 degrader-10 | PROTAC SOS1 degrader-10 is a SOS1 PROTAC degrader dependent on CRBN and the proteasome. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS-mutant cancer cells SW620, A549 and DLD-1, with DC50 values of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits ERK phosphorylation. PROTAC SOS1 degrader-10 suppresses the proliferation of KRAS-mutant cancer cells via antiproliferative activity. PROTAC SOS1 degrader-10 can be used in studies related to KRAS-mutant cancers. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
