3046228-11-6
3046228-11-6
Chemical Structure
KDM5B-IN-4
- CAS No.: 3046228-11-6
- Formula:C30H30N6O
- Molecular Weight:490.60
IUPAC Name: N-(2-(4-methylpiperazin-1-yl)ethyl)-6-(naphthalen-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
InChIKey: WFWPZTUQBCWFTE-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)CCNC(C2=CC(C3=CC=C4C=CC=CC4=C3)=NC5=C2C=NN5C6=CC=CC=C6)=O
Biological Activity: KDM5B-IN-4 (compound 11ad) is a lysine demethylase 5B (KDM5B) inhibitor with an IC50 of 0.025 μM KDM5B-IN-4 increases substrate H3K4me1/2/3 level by inhibiting KDM5B in PC-3 cells. KDM5B-IN-4 downregulates PI3K/AKT. KDM5B-IN-4 reduces tumor volume in mice and shows less toxic to organs[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KDM5B-IN-4 | 99.56% | KDM5B-IN-4 (compound 11ad) is a lysine demethylase 5B (KDM5B) inhibitor with an IC50 of 0.025 μM KDM5B-IN-4 increases substrate H3K4me1/2/3 level by inhibiting KDM5B in PC-3 cells. KDM5B-IN-4 downregulates PI3K/AKT. KDM5B-IN-4 reduces tumor volume in mice and shows less toxic to organs. | ||||||||||||||||||||
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