3046378-98-4
3046378-98-4
Chemical Structure
SGK1-IN-6
- CAS No.: 3046378-98-4
- Formula:C30H30F3N5O4
- Molecular Weight:581.59
InChIKey: LUUSQGGJIVYGID-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C(F)(F)F)C=C(NC3=CC=C(N4CCNCC4)C=C3OC)N=C2C=C1OC)NC5=CC=C(C=C5)OC
Biological Activity: SGK1-IN-6 is a selective SGK1 inhibitor with an IC50 of 0.39 μM, showing selectivity over SGK2/3. SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer[1].
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SGK1-IN-6 | SGK1-IN-6 is a selective SGK1 inhibitor with an IC50 of 0.39 μM, showing selectivity over SGK2/3. SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer. | |||||||||||||||||||||
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