3047343-70-1
3047343-70-1
Chemical Structure
IRAK1-IN-1
- CAS No.: 3047343-70-1
- Formula:C17H20N2O4
- Molecular Weight:316.35
InChIKey: RZEKPXJLOYIHJQ-UHFFFAOYSA-N
SMILES: CC(N1CCN(CC1)CCOC2=CC(OC3=CC=CC=C23)=O)=O
Biological Activity: IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC50 values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS (HY-D1056)-induced acute lung injury (ALI) and DSS(HY-116282C)-induced colitis in mice[1].
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IRAK1-IN-1 | IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC50 values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS (HY-D1056)-induced acute lung injury (ALI) and DSS(HY-116282C)-induced colitis in mice. | |||||||||||||||||||||
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