3047411-80-0
3047411-80-0
Chemical Structure
FXIIa-IN-5
- CAS No.: 3047411-80-0
- Formula:C26H29N7O
- Molecular Weight:455.55
InChIKey: QMKLOIDZBNHGIV-UHFFFAOYSA-N
SMILES: O=C(C1=C2C(C=CC=C2)=C(C=C1)N3CCN(CCC3)C(C)C)N4N=C(N=C4N)C5=CC=CC=N5
Biological Activity: FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474)-induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg)[1].
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FXIIa-IN-5 | FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474)-induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg). | |||||||||||||||||||||
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