3048071-20-8
Chemical Structure
5-HT1AR agonist 1
- CAS No.: 3048071-20-8
- Formula:C24H26N4O3
- Molecular Weight:418.49
InChIKey: PNWDDBIQRUDOOS-UHFFFAOYSA-N
SMILES: NC(C1=CC2=C(O1)C=CC(N3CCN(CCC4=CC=C(CCC(N5)=O)C5=C4)CC3)=C2)=O
Biological Activity: 5-HT1AR agonist 1 (Compound A3) emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC50 value of 34 nM, SERT reuptake ihibitor (IC50 =12 nM), NET reuptake inhibitor (IC50 =78 nM) and DAT reuptake inhibitor (IC50 =135 nM). 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs[1].
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5-HT1AR agonist 1 | 5-HT1AR agonist 1 (Compound A3) emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC50 value of 34 nM, SERT reuptake ihibitor (IC50 =12 nM), NET reuptake inhibitor (IC50 =78 nM) and DAT reuptake inhibitor (IC50 =135 nM). 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs. | |||||||||||||||||||||
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