3048341-50-7
3048341-50-7
Chemical Structure
JL-15-DNBS
- CAS No.: 3048341-50-7
- Formula:C34H32ClN5O8S
- Molecular Weight:706.16
InChIKey: DJQAOLNFIJVZBY-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)(OC2=CC(C3=CC=C(OC4=CC(C)=C(Cl)C(C)=C4)C=C3)=CC(NCCN5CCCCC5)=C2C#N)=O
Biological Activity: JL-15-DNBS is an Hsp70-Bim interaction disruptor. JL-15-DNBS undergoes GSH-responsive activation to release active JL-15, and GSH depletion attenuates its cytotoxicity. JL-15-DNBS downregulates the oncogenic client proteins AKT and eIF4E. JL-15-DNBS can be used for research on chronic myeloid leukemia (CML)[1].
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JL-15-DNBS | JL-15-DNBS is an Hsp70-Bim interaction disruptor. JL-15-DNBS undergoes GSH-responsive activation to release active JL-15, and GSH depletion attenuates its cytotoxicity. JL-15-DNBS downregulates the oncogenic client proteins AKT and eIF4E. JL-15-DNBS can be used for research on chronic myeloid leukemia (CML). | |||||||||||||||||||||
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