3048608-87-0
3048608-87-0
Chemical Structure
MW073
- CAS No.: 3048608-87-0
- Formula:C22H27N5
- Molecular Weight:361.48
InChIKey: IBOOAZHRKKSRLF-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)CCNC2=NN=C(C=C2C)C3=CC=C4C=CC=CC4=C3
Biological Activity: MW073 is a highly selective and orally active 5-HT2BR antagonist (IC50 =70 nM). MW073 exerts its effects by concentration-dependently inhibiting receptor activity and β-arrestin-1 recruitment. MW073 ameliorates synaptic plasticity and behavioral deficits, including aggression, in Alzheimer’s disease (AD) mouse models. MW073 can be used for Alzheimer’s disease (AD) research[1][2].
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MW073 | MW073 is a highly selective and orally active 5-HT2BR antagonist (IC50 =70 nM). MW073 exerts its effects by concentration-dependently inhibiting receptor activity and β-arrestin-1 recruitment. MW073 ameliorates synaptic plasticity and behavioral deficits, including aggression, in Alzheimer’s disease (AD) mouse models. MW073 can be used for Alzheimer’s disease (AD) research. | |||||||||||||||||||||
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