3048633-11-7
3048633-11-7
Chemical Structure
PI3Kδ-IN-21
- CAS No.: 3048633-11-7
- Formula:C19H16ClN9
- Molecular Weight:405.84
InChIKey: VJANIOXYVBRDKG-JTQLQIEISA-N
SMILES: C[C@@H](C1=CN(C2=CC(Cl)=CN=C21)C3=CC=CN=C3)NC4=NC(N)=NC(N)=C4C#N
Biological Activity: PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC50 of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model[1].
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PI3Kδ-IN-21 | PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC50 of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model. | |||||||||||||||||||||
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