3048634-52-9
3048634-52-9
Chemical Structure
RET/TRKA-IN-1
- CAS No.: 3048634-52-9
- Formula:C30H31N9O
- Molecular Weight:533.63
InChIKey: QSVQKCPNBUWEOG-UHFFFAOYSA-N
SMILES: CN1N=CC(C2=CC=C(C3=C(NC4=CC=C(CC(NC5=CC(C(C)(C)C)=NN5C)=O)C=C4)N=CN=C3N6)C6=C2)=C1
Biological Activity: RET/TRKA-IN-1 (Compound 13) is a dual inhibitor for RET (IC50=0.375 µM) and TRKA. RET/TRKA-IN-1 inhibits cell viability of LC-2 and KM12, with GI50 of 0.72 and 0.25 μM. RET/TRKA-IN-1 arrests the cell cycle at G1 phase[1].
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RET/TRKA-IN-1 | RET/TRKA-IN-1 (Compound 13) is a dual inhibitor for RET (IC50=0.375 µM) and TRKA. RET/TRKA-IN-1 inhibits cell viability of LC-2 and KM12, with GI50 of 0.72 and 0.25 μM. RET/TRKA-IN-1 arrests the cell cycle at G1 phase. | |||||||||||||||||||||
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