3049618-45-0
3049618-45-0
Chemical Structure
Antitumor agent-111
- CAS No.: 3049618-45-0
- Formula:C34H29ClF2N6O5
- Molecular Weight:675.08
InChIKey: IHGSZTNAKJVXBU-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C2=CC=C(F)C(Cl)=C2)C3=C(C=CC=N3)C1=O)NC4=CC=C(OC5=CC(C(NCCCN6CCOCC6)=O)=NC=C5)C(F)=C4
Biological Activity: Antitumor agent-111 (compound 46) is an c-Met kinase inhibitor (IC50=46 nM) with antitumor and antiproliferative activity. Antitumor agent-111 arrests cell cycle at G0/G1 phase, and induces apoptosis[1].
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Antitumor agent-111 | Antitumor agent-111 (compound 46) is an c-Met kinase inhibitor (IC50=46 nM) with antitumor and antiproliferative activity. Antitumor agent-111 arrests cell cycle at G0/G1 phase, and induces apoptosis. | |||||||||||||||||||||
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