3049740-77-1

Tubulin/HDAC-IN-2 Chemical Structure
3049740-77-1

Chemical Structure

Tubulin/HDAC-IN-2

  • CAS No.: 3049740-77-1
  • Formula:C21H19FN2O4
  • Molecular Weight:382.38

InChIKey: KTNKYIOGJFVNSI-UHFFFAOYSA-N

SMILES: O=C(NO)C(F)OC1=CC(C(C2=CC(C)=NC3=CC=CC=C23)=C)=CC=C1OC

Biological Activity: Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC50 of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell apoptosis. Tubulin/HDAC-IN-2 inhibits the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model[1].

Cat. No. Product Name Purity Description Pricing
HY-155523 		Tubulin/HDAC-IN-2 Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC50 of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell apoptosis. Tubulin/HDAC-IN-2 inhibits the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model.
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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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