3050836-94-4
3050836-94-4
Chemical Structure
TLR4/NF-κB-IN-1
- CAS No.: 3050836-94-4
- Formula:C20H15FN6O
- Molecular Weight:374.37
InChIKey: AYLKFMSUECMRIU-UHFFFAOYSA-N
SMILES: FC1=CC=C(CN2C=CC3=C(NC4=CC(NC(N5)=O)=C5C=C4)N=CN=C32)C=C1
Biological Activity: TLR4/NF-κB-IN-1 (Compound 7x) is an orally available inhibitor that specifically targets the TLR4/NF-κB signaling pathway, offering anti-inflammatory effects and the ability to cross the blood-brain barrier. TLR4/NF-κB-IN-1 can reduce acute neuroinflammation in mice caused by LPS (HY-D1056) and downregulate the expression of TLR4, P-NF-κB and P-IκB-α proteins[1].
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TLR4/NF-κB-IN-1 | 99.92% | TLR4/NF-κB-IN-1 (Compound 7x) is an orally available inhibitor that specifically targets the TLR4/NF-κB signaling pathway, offering anti-inflammatory effects and the ability to cross the blood-brain barrier. TLR4/NF-κB-IN-1 can reduce acute neuroinflammation in mice caused by LPS (HY-D1056) and downregulate the expression of TLR4, P-NF-κB and P-IκB-α proteins. | ||||||||||||||||||||
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