3051812-84-8
Chemical Structure
Gal-dMor-Gem
- CAS No.: 3051812-84-8
- Formula:C41H53F2N5O18
- Molecular Weight:941.88
InChIKey: WFGLJCOVIJNVJR-MTGDKXRSSA-N
SMILES: O=C(OCC1=CC(CN2CCOCC2)=C(O[C@H]3[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O3)C(CN4CCOCC4)=C1)NC5=NC(N(C=C5)[C@@H]6O[C@@H]([C@H](C6(F)F)O)CO)=O
Biological Activity: Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence[1].
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Gal-dMor-Gem | Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence. | |||||||||||||||||||||
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