3052405-64-5
3052405-64-5
Chemical Structure
TRK/ALK-IN-1
- CAS No.: 3052405-64-5
- Formula:C31H35ClF2N8O2S
- Molecular Weight:657.18
IUPAC Name: N-(4-(tert-butyl)phenyl)-4-(5-cyanopyridin-2-yl)piperazine-1-carboxamide
InChIKey: NZIBMWIIYQHEQI-MHZLTWQESA-N
SMILES: CN1CCN(CC1)C2=CC=C(C=C2C(N3CCSCC3)=O)NC([C@@H]4CCCN4C5=NC(NC6=CC(F)=CC(F)=C6)=NC=C5Cl)=O
Biological Activity: TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of TRK and ALK. TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC50 values of 2.2, 9.3 and 38 nM towards TRKA, ALKWT and ALKL1196M, respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases[1].
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TRK/ALK-IN-1 | TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of TRK and ALK. TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC50 values of 2.2, 9.3 and 38 nM towards TRKA, ALKWT and ALKL1196M, respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases. | |||||||||||||||||||||
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