3052839-42-3
3052839-42-3
Chemical Structure
P-gp/BCRP-IN-2
- CAS No.: 3052839-42-3
- Formula:C32H35N3O6
- Molecular Weight:557.64
InChIKey: UZOFFAHSLWQYJI-DHZHZOJOSA-N
SMILES: COC1=CC(/C=C/C2=NN=C(O2)C(C=C3)=CC=C3CCN4CCC5=CC(OC)=C(OC)C=C5C4)=CC(OC)=C1OC
Biological Activity: P-gp/BCRP-IN-2 (compound 15) is an oxadiazole derivative and a dual inhibitor of the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). P-gp/BCRP-IN-2 also enhances the anti-proliferative effects of Doxorubicin (HY-15142A) in drug-resistant human adenocarcinoma colon cancer cell lines HT29/DX and MDCK-MDR1 cells[1].
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P-gp/BCRP-IN-2 | P-gp/BCRP-IN-2 (compound 15) is an oxadiazole derivative and a dual inhibitor of the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). P-gp/BCRP-IN-2 also enhances the anti-proliferative effects of Doxorubicin (HY-15142A) in drug-resistant human adenocarcinoma colon cancer cell lines HT29/DX and MDCK-MDR1 cells. | |||||||||||||||||||||
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