3054043-85-2
Chemical Structure
PD-L1/Nampt-IN-1
- CAS No.: 3054043-85-2
- Formula:C28H28N4O2
- Molecular Weight:452.55
IUPAC Name: N-(2-(((2-methoxy-6-(2-methyl-[1,1'-biphenyl]-3-yl)pyridin-3-yl)methyl)amino)ethyl)nicotinamide
InChIKey: LAWJEYCPOCTNIU-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(C2=C(C(C3=CC=CC=C3)=CC=C2)C)=N1)CNCCNC(C4=CN=CC=C4)=O
Biological Activity: PD-L1/Nampt-IN-1 is an orally active inhibitor that simultaneously target PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase) with IC50s value of 63 nM and 582 nM. PD-L1/Nampt-IN-1 demonstrates cross-species affinity with comparable KD values for hPD-L1 (52.6 nM) and mPD-L1 (49.1 nM), respectively. PD-L1/Nampt-IN-1 effectively inhibits tumor growth by activating the tumor immune microenvironment. PD-L1/Nampt-IN-1 can be used for the study of melanoma[1].
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PD-L1/Nampt-IN-1 | PD-L1/Nampt-IN-1 is an orally active inhibitor that simultaneously target PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase) with IC50s value of 63 nM and 582 nM. PD-L1/Nampt-IN-1 demonstrates cross-species affinity with comparable KD values for hPD-L1 (52.6 nM) and mPD-L1 (49.1 nM), respectively. PD-L1/Nampt-IN-1 effectively inhibits tumor growth by activating the tumor immune microenvironment. PD-L1/Nampt-IN-1 can be used for the study of melanoma. | |||||||||||||||||||||
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