3054116-24-1
Chemical Structure
SD-2301
- CAS No.: 3054116-24-1
- Formula:C64H80N13O15PS2
- Molecular Weight:1366.50
InChIKey: NDCOUHYOBDYRRK-IHBGDBLYSA-N
SMILES: O=C([C@@H](NC([C@@H]1CC[C@@H]2CCN(C[C@@H](C(N12)=O)NC(C3=CC4=C(N3)C=CC(C(P(O)(O)=O)=O)=C4)=O)C(CCCCC5=CN(N=N5)[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)O)=O)=O)=O)CCC(N)=O)NCC(C=C9)=CC=C9S(=O)(CC)=O
Biological Activity: SD-2301 is a selective STAT3 PROTAC degrader with a DC50 of 4 nM. By bridging the target protein STAT3 and VHL-1 E3 ubiquitin ligase, SD-2301 induces efficient degradation of STAT3 via the ubiquitin-proteasome system, thereby exerting potent anti-tumor and immunomodulatory effects. SD-2301 can be used in research related to lymphoma, melanoma, colon cancer and other tumors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SD-2301 | 99.89% | SD-2301 is a selective STAT3 PROTAC degrader with a DC50 of 4 nM. By bridging the target protein STAT3 and VHL-1 E3 ubiquitin ligase, SD-2301 induces efficient degradation of STAT3 via the ubiquitin-proteasome system, thereby exerting potent anti-tumor and immunomodulatory effects. SD-2301 can be used in research related to lymphoma, melanoma, colon cancer and other tumors. | ||||||||||||||||||||
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References
- [1]. Zhou J, et al. STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity. Nature. 2025 Jul;643(8071):519-528. [Content Brief]
- [2]. Acharyya RK, et al. Discovery of SD-2301 as a Highly Potent and Selective PROTAC STAT3 Degrader Capable of Achieving Complete Tumor Regression with Single Administration. J Med Chem.
