3054217-03-4
3054217-03-4
Chemical Structure
Prostaglandin E2 Inhibitor 3
- CAS No.: 3054217-03-4
- Formula:C21H14BrN3O2S
- Molecular Weight:452.32
InChIKey: WRBRJSBQVMFDGA-UHFFFAOYSA-N
SMILES: O=C(C1=C(Br)C=CC=C1)NC2=NN=C(C3=CC=C(C4=CC(O)=CC=C4)C=C3)S2
Biological Activity: Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50 = 0.2 µM). Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX)-1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH). Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice[1].
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Prostaglandin E2 Inhibitor 3 | Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50 = 0.2 µM). Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX)-1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH). Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice. | |||||||||||||||||||||
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