3055155-53-5
Chemical Structure
NLRP3-IN-93
- CAS No.: 3055155-53-5
- Formula:C19H24N6O
- Molecular Weight:352.43
InChIKey: WJLKINVKKGUJCF-CQSZACIVSA-N
SMILES: CC1=C(C2=NC3=NC(N[C@H]4CN(C)CCC4)=NN3C=C2)C(O)=CC(C)=C1
Biological Activity: NLRP3-IN-93 is an orally active, blood-brain barrier-permeable NLRP3 inhibitor. NLRP3-IN-93 binds to the NACHT domain, blocks inflammasome assembly, and inhibits downstream IL-1β release, without significantly inhibiting various CYP isoforms. NLRP3-IN-93 demonstrates dose-dependent efficacy in mouse models of acute inflammation and Parkinson's disease, and exhibits good tolerability and an acceptable safety window in rats and dogs. NLRP3-IN-93 can be used in research on Parkinson's disease[1].
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NLRP3-IN-93 | NLRP3-IN-93 is an orally active, blood-brain barrier-permeable NLRP3 inhibitor. NLRP3-IN-93 binds to the NACHT domain, blocks inflammasome assembly, and inhibits downstream IL-1β release, without significantly inhibiting various CYP isoforms. NLRP3-IN-93 demonstrates dose-dependent efficacy in mouse models of acute inflammation and Parkinson's disease, and exhibits good tolerability and an acceptable safety window in rats and dogs. NLRP3-IN-93 can be used in research on Parkinson's disease. | |||||||||||||||||||||
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