3056070-96-0
Chemical Structure
FAPI-X5
- CAS No.: 3056070-96-0
- Formula:C63H88F2IN15O13
- Molecular Weight:1428.37
InChIKey: CYTHSBKYHUAKID-PJLNTLIASA-N
SMILES: OC(CN1CCN(CC(O)=O)CCN(CC(NCCCC[C@H](NC(CCCC2=CC=C(I)C=C2)=O)C(N[C@@H](CCCNC(N)=N)C(N3CCC(CCCOC4=CC=C(N=CC=C5C(NCC(N6CC(F)(F)C[C@H]6C#N)=O)=O)C5=C4)CC3)=O)=O)=O)CCN(CC(O)=O)CC1)=O
Biological Activity: FAPI-X5 is a fibroblast activation protein (FAP) inhibitor. FAPI-X5 binds to the FAP catalytic domain, forming hydrogen bonds with key active residues and engaging in π-π stacking to drive functional inhibition. FAPI-X5 exhibits albumin binding activity to prolong systemic circulation half-life. FAPI-X5 induces cytostatic effects on glioblastoma tumors, slowing tumor growth without regression. FAPI-X5, when labeled with 68Ga, acts as a PET tracer with rapid tumor uptake and high-contrast imaging in glioblastoma tumor-bearing mice. FAPI-X5, when labeled with 177Lu or 47Sc, functions as a targeted radionuclide agent with prolonged tumor retention. FAPI-X5 can be used for the research of glioblastoma[1].
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FAPI-X5 | FAPI-X5 is a fibroblast activation protein (FAP) inhibitor. FAPI-X5 binds to the FAP catalytic domain, forming hydrogen bonds with key active residues and engaging in π-π stacking to drive functional inhibition. FAPI-X5 exhibits albumin binding activity to prolong systemic circulation half-life. FAPI-X5 induces cytostatic effects on glioblastoma tumors, slowing tumor growth without regression. FAPI-X5, when labeled with 68Ga, acts as a PET tracer with rapid tumor uptake and high-contrast imaging in glioblastoma tumor-bearing mice. FAPI-X5, when labeled with 177Lu or 47Sc, functions as a targeted radionuclide agent with prolonged tumor retention. FAPI-X5 can be used for the research of glioblastoma. | |||||||||||||||||||||
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