3057531-85-5
3057531-85-5
Chemical Structure
GPX4 degrader-1
- CAS No.: 3057531-85-5
- Formula:C38H36ClN3O4
- Molecular Weight:634.16
InChIKey: BVSAMFIVZMUKKQ-ILFWFZRHSA-N
SMILES: O=C(OC)[C@@H](C1)N(C(CCl)=O)[C@@H](C2=CC=C(C(NCCCC(C3=CC=CC=C3)C4=CC=CC=C4)=O)C=C2)C5=C1C6=CC=CC=C6N5
Biological Activity: GPX4 degrader-1 (Compound RS-1) is a hydrophobic tagging (HyT)-mediated GPX4 degrader (DC50: 8.9 nM in HT1080 cells) GPX4 degrader-1 induces GPX4 degradation. GPX4 degrader-1 induces Ferroptosis. GPX4 degrader-1 increases lipid ROS. GPX4 degrader-1 demonstrates potent antitumor efficacy in a murine mammary carcinoma model[1].
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GPX4 degrader-1 | GPX4 degrader-1 (Compound RS-1) is a hydrophobic tagging (HyT)-mediated GPX4 degrader (DC50: 8.9 nM in HT1080 cells) GPX4 degrader-1 induces GPX4 degradation. GPX4 degrader-1 induces Ferroptosis. GPX4 degrader-1 increases lipid ROS. GPX4 degrader-1 demonstrates potent antitumor efficacy in a murine mammary carcinoma model. | |||||||||||||||||||||
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